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Work-Related Diseases
Find information on occupational work-related diseases including diseases, category and group, synonyms, severity, latency, risk factors, signs and symptoms, diagnosis, prognosis, and treatments and options.
Beryllium, chronic toxic effect
Occupational Disease Beryllium, chronic toxic effect
Beryllium, chronic toxic effect Category Interstitial Lung Disease
Beryllium, chronic toxic effect Severity Chronic
Beryllium, chronic toxic effect Synonyms Chronic beryllium disease; beryllium pneumoconiosis; Berylliosis
Information on Beryllium, chronic toxic effect Symptoms, Diagnosis, Prognosis, Screening and Imaging Acute beryllium disease has not been seen in the United States since beryllium was banned in the fluorescent and neon lamp industries in the 1960s. Chronic beryllium disease is a granulomatous interstitial pneumonitis caused by a cell mediated, delayed hypersensitivity. It develops in only 1 to 3% of those exposed. Patients present with dyspnea on exertion. Chronic beryllium disease (CBD) is indistinguishable from sarcoidosis by older criteria; it is now diagnosed by LTT (lymphocyte transformation test). [ATSDR Case Studies] The blood test for lympocyte proliferation (also called "BeLPT" for beryllium lympocyte proliferation test) may also be useful in screening beryllium exposed workers. [Harber, p. 494] CBD has been diagnosed in workers exposed below the OSHA permissible exposure limit of 2 ug/m3 and in factories that used only 2% beryllium copper alloy. [J Occup Environ Med 1999 Apr;41(4):304-8] In addition to dyspnea, cough, fatigue, anorexia, and weight loss, symptoms of CBD may include fever, arthralgias, and chest pain. [Harber, p. 491]
Beryllium, chronic toxic effect Latency Few months to 40 years [Harber, p. 491]
Beryllium, chronic toxic effect References http://www.nationaljewish.org/medfacts/beryllium_medfact.html
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