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Category Archives: Skin
Linear IgA Disease
Linear IgA Disease
Clinical features: children or adults with pruritic bullae throughout, associated drug sensitivity
Skin lesion appearance: erythematous base
Histology: identical to dermatitis herpetiformis
Immunofluorescence: linear IgA at basement membrane not dermal papillae
Posted in Skin
Tagged Blister, Blistering diseases, Blistering skin diseases, Bullous skin diseases, IgA, Linear IgA, Linear IgA Disease
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Transient acantholytic dyskeratosis
Transient acantholytic dyskeratosis
- Spongiotic dermatitis
- Hailey-Hailey
- Darier’s
- Pemphigus vulgaris
Posted in Skin
Tagged Acantholytic dyskeratosis, Darier’s disease, Dyskeratoses, Dyskeratosis, Hailey-Hailey disease, Pemphigus vulgaris, Spongiotic dermatitis, Transient acantholytic dyskeratosis
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Epidermolysis Bullosa
Epidermolysis Bullosa
Clinical features: > greater than 12 genetic disorders
- blisters form shortly after birth
- hands, elbows, knees
Histology:
- subepidermal blister; superficial dermis is fibrotic
- little to no inflammation
Immunofluorescence:
- linear deposits on epidermal-dermal basement – IgG and Complement C3
Electron microscopy: for classification
Posted in Skin
Tagged Blistering skin diseases, Bullous diseases, Epidermolysis, Epidermolysis Bullosa, Subepidermal, Subepidermal blister, Subepidermal blistering
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Dermatitis Herpetiformis Histology
Dermatitis Herpetiformis Histology
Cause: autoimmune
Clinical features:
- young adults, associated with celiac disease, on extensor surfaces (“extends from skin to small bowel with celiac disease”), intensely pruritic
- anti-endomyseal, anti-gliadin, anti-transglutaminase antibodies
- HLA DR3, B8
Gross appearance: uriticarial plaques and vesicles
Histology:
- no acantholysis
- sub-epidermal blister with fibrin and neutrophils,eosinophils at tips of papillae “microabscesses and vacuolization”
- can spread along epidermal-dermal junction
fibrin
Immunofluorescence: granular deposits at tips of dermal papillae, IgA
Treatment: gluten-free diet
Posted in Skin
Tagged Blistering diseases, Bullous skin diseases, Dermatitis Herpetiformis, Dermatitis Herpetiformis Antibodies, Dermatitis Herpetiformis Blisters, Dermatitis Herpetiformis Features, Dermatitis Herpetiformis Histology, Dermatitis Herpetiformis skin changes, Dermatitis Herpetiformis Skin Histology, Subepidermal, Subepidermal blistering
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Bullous Pemphigoid
Bullous Pemphigoid
Cause: autoimmune
Clinical appearance: elderly, flexor surfaces
Gross appearance: tense bullae that do not rupture easily since bullae are below epidermis
- ? no acantholysis
- ? sub-epidermal blister with fibrin
- ? PVLI w/ ef + nf
Immunofluorescence:
- linear at epidermal-dermal junction
- IgG and complement C3 (bind to hemidesmosomes)
Posted in Skin
Tagged Blistering skin diseases, Blisters, Bullous disease, Bullous pemphigoid, Pemphigoid, Subepidermal blister, Subepidermal Bullous Lesions
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Darier’s Disease
Darier’s Disease
Clinical appearance: neck and trunk
Gross: symmetrical distribution of red-brown keratotic papules
Histology
- suprabasal clefts, dyskeratotic, basophilic cells with large nuclei and a paranuclear halo (grains or corps ronds (granular layer and stratum))
- acanthosis and papillomatosis
Posted in Skin
Tagged Blistering skin disease, Blisters, Corps, Darier's Disease, Grains, Ronds, Suprabasal, Suprabasal blister
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Impetigo
Impetigo
Cause: kids and adults: Staphylococcus aureus ? toxins A and B, which target desmoglein-1
- Streptococcal variant associated with SSSS
Gross appearance: crusted pustules
Histology
- subcorneal bulla with neutrophils beneath stratum corneum, “subcorneal pustule” ; roof of pustule is parakeratotic stratum corneum
Histochemistry
- Gram + for bacteria
Pemphigus Vulgaris
Pemphigus Vulgaris
Cause: antibodies directed against demosomes protein, desmoglein-3
Clinical presentation: oral and skin
Gross: bulla, blisters→rupture easily because not below epidermis
Microscopy:
▪ acantholysis → cells become rounded
▪ “tombstones” → (i.e. “vulgar”)
Immunofluorescence
- fishnet pattern → IgG and C3 in lesional and non-lesional skin
Posted in Skin
Tagged Acantholysis, desmoglein-3, Desmosome, Immunofluorescence, Pemphigus, Pemphigus vulgaris, Suprabasal blister, tomstoning
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Pemphigus Foliaceous
Pemphigus Foliaceous
- subcorneal blister
- involves granulosa cell layer (see content for pemphigus vulgaris)
- antibodies against desmoglein-1
Posted in Skin
Tagged Blistering disease, Desmoglein-1, Pemphigus, Pemphigus Foliaceous, Subcorneal blister
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Bullous diseases
Bullous diseases
1. Subcorneal
- Pemphigus foliaceous
- Staphylococcal scalded skin syndrome
- Impetigo
2. Suprabasal
- Pemphigus vulgaris
- Darier’s disease
3. Subepidermal
- Bullous pemphigoid
- Dermatitis herpetiformis
- linear IgA dermatosis
- epidermolysis bullosa
Posted in Skin
Tagged Blister, Blistering diseases, Blistering skin diseases, Bullous diseases, Bullous lesions, Bullous skin diseases, Subcorneal, Subcorneal blister, Subepidermal, Subepidermal blister, Suprabasal, Suprabasal blister
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