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Category Archives: Pancreas
Endocrine Cells
Pancreatic Endocrine Cells
- produce and secrete insulin, glucagon and somatostatin
- the cells are termed islet cells
VIPoma
Vasoactive Intestinal Peptide Producing Tumor
VIPoma
Neuroendorine tumor
-nested, trabecular, acinar or solid pattern
-uniform cells with a fair amount of acidophilic cytoplasm
-centrally placed nucleus
-“endocrine atypia” may be seen
Electron Microscopy
– membrane bound neurosecretory granules
Immunohistochemistry
- chromogranin and synaptophysin +
- immnohistochemistry for various hormone markers ( ie. VIP) may not work and does not correlate with functionality of the tumor.
Diagnosis
– this is a clinical diagnosis secondary to the excess hormone effects which include:
watery diarrhea, hypokalemia, and achlorhydria (WDHA) triad is what is characteristic of functional vasoactive peptide producing tumors. VIPomas in adults originate commonly in the pancreas, but originate extremely rarely in the pancreas of affected children. Instead, WDHA syndrome is usually associated with VIP-secreting neurogenic tumors involving the retroperitoneum and mediastinum in children.
Posted in Pancreas
Tagged , achlorhydria, hypokalemia, Pancreas, vasoactive intestinal peptide producing tumor, vipoma, watery diarrhea, wdha triad
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Cyst Prognosis
Pancreas Cyst Prognosis
Serous – excellent with minimal malignant transformation
Mucinous cystic neoplasm – prognosis dependent on absence of invasive carcinoma ( associated in 1/3) and adequacy of resection
IPMN- prognosis dependent on absence of invasive carcinoma and adequacy of resection
Solid pseudopapillary – most follow a benign course if adequately resected
Serous Cyst
Serous Pancreatic Cyst
-well-circumscribed nodules with central scar grossly
-can be micro oligo or lined by flat cuboidal cells
-microcystic variant has many small cysts
-oligocystic variant has a number of cysts such than one could actually count them