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Category Archives: Ovary
Ovarian Tumor Like Conditions
Ovarian Tumor Like Conditions
- luteoma of pregnancy
- stroma hyperthecosis (bilateral, estrogenic)
- stromal hyperplasia
- fibromatosis
- massive ovarian edema (stromal edema and dilated follicles, secondary to hCG)
Posted in Ovary
Tagged Fibromatosis, luteoma of pregnancy, massive ovarian edema, Ovarian Tumor Like Conditions, Ovarian Tumor Like Lesions, Ovary Tumor Like Conditions, stroma hyperthecosis, stromal hyperplasia
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Ovarian Choriocarcinoma
Choriocarcinoma
Ovarian Choriocarcinoma
- can develop in 3 ways:
1. metastatic to ovary
2. from an ovarian pregnancy (gestational type)
3. from germ cell neoplasm (non-gestational type)
Gross: hemorrhagic and necrotic
Histology:
- mononuclear and multinuclear synctial cells, cytotrophblast and syncytiotrophoblast cells with hemorrhage and necrosis
Immunohistochemistry:
- hCG
Posted in Ovary
Tagged Choriocarcinoma, Choriocarcinoma Immunohistochemistry, cytotrophblast, Ovarian Choriocarcinoma, syncytiotrophoblast
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Tumors of the Rete Ovarii
Tumors of the Rete Ovarii
- adenoma, adenocarcinoma, cystadenoma, cystadenofibroma
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Tagged adenocarcinoma, adenoma, cystadenofibroma, cystadenoma, Rete Ovarii, Tumors of the Rete Ovarii
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Gonadoblastoma
Gonadoblastoma
- dysgerminoma (germ cell) and Sertoli, Granulosa cells (sex-cord)
Ovarian Yolk Sac Tumor
Yolk Sac Tumor
Ovarian Yolk Sac Tumor
Clinical: increase in ↑ serum AFP in most
Gross: large, cystic solid +/- hemorrhage, necrosis
Histology:
Variants of yolk sac tumors
- endodermal sinus pattern (Schiller-Duval bodies) – microcystic (reticular)
- others: hepatoid, polyvesicular vitelline, solid, glandular
- hyaline globules (DPAS, AFP, AAT+) (outside cells)
Immunohistochemistry:
-AFP diffuse, cytokeratin
Posted in Ovary
Tagged afp, alpha feto protein, endodermal sinus pattern, germ cell tumor, glandular, hepatoid, hyaline globules, microcystic, mixed germ cell tumor, Ovarian Yolk Sac Tumor, polyvesicular vitelline, schiller-duval bodies, solid, Yolk Sac Tumor
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Embryonal Carcinoma
Embryonal Carcinoma
Clinical: 30 years old
Gross: large, friable, foci hemorrhagic and necrotic, firm and gray
Histology
- usually part of a mixed germ cell tumor
- STP pattern
- ill-defined cell borders
- atypical cells, large nuclei, large nucleoli
- nuclear overlapping
- coagulative necrosis
- mitoses
- significant vascular invasion
Immunohistochemistry
- CD30
-Cytokeratin
POLYEMBRYOMA (embyronal carcinoma with embryoid bodies)
Posted in Ovary
Tagged Embryonal Cancer, Embryonal Carcinoma, Embryonal Carcinoma of the Ovary, Germ Cell, germ cell tumor, mixed germ cell tumor, Ovarian Embryonal Carcinoma, Polyembryoma
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Dysgerminoma
Dysgerminoma
- female counterpart of seminoma
Clinical: 40 years old female, mass, pain, elevated ↑ serum β-hCG,
Gross appearance: solid gray (rare hemorrhage and necrosis)
Histology
- fibrous bands with lymphocytes (also mingle with seminoma cells)
- sheets of polygonal cells with clear to eosinophilic cytoplasm
- central nuclei with 1-2 nucleoli
- granulomatous reaction
Immunohistochemistry and Special Stains
- PAS (glycogen)
- c-kit
- PLAP
- synctiotroblast-like cells → bhCG +
Prognosis:
- excellent, treat with oophorectomy
Variants:
- germinoma with trophoblast giant cells
- germinoma with yolk sac elements
- germinoma with early carcinomatous differentiation (> 30 mitoses / 10 HPF)
Sertoli Leydig Cell Tumor
Sertoli Leydig Cell Tumor
Clinical: more common in young women
Sertoli-Leydig cell tumor
Sertoli cell tumor (small hollow tubules or cords → try to recapituate seminiferous tubules)
Leydig cell tumor (eosinophilic cytoplasm with crystals of Renke)
Hilus cell tumor (eosinophilic cytoplasm)
Steroid cell tumor (lipid laden cells)
Gynandroblastoma (granulosa and Sertoli cells)
Posted in Ovary
Tagged Gynandroblastoma, Leydig, Renke, Renke crystals, Sertoli, Sertoli Leydig, Sertoli Leydig Cell, Sertoli Leydig Cell Tumor
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Thecoma
Thecoma
Histology: oval-spindle cells with lipid-rich cytoplasm, bands of dense collagen
Special stains: oil red O, reticulin around individual cells
Lutenized thecoma
Histology: eosinophilic, abundant cytoplasm, central nucleus with nucleoli
Fibroma-Thecoma
Stromal luteoma
Sclerosing stromal tumour
*Can have sex-cord elements
Posted in Ovary
Tagged Fibroma Thecoma, lutein supplement, oil red O, Ovary, Ovary thecoma, Reticulin, Sclerosing stromal tumour, Stromal luteoma, Thecoma
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Ovary Fibroma
Fibroma
Clinical: post-menopausal women
Meigs’ syndrome
- right pleural effusion, ascites, ovarian fibroma
Gross: solid yellow, white
Fibroma
Histology: bland spindle cells, no atypia, no mitoses, storiform
Cellular fibroma:
Histology: cellular, no significant atypia, < 3 mitoses /10 HPF
Fibrosarcoma:
Histology: > 4 mitoses /10 HPF, atypia and cellular
Posted in Ovary
Tagged Fibroma, Fibroma Thecoma, Fibrosarcoma, Lutenized thecoma, Meigs’ syndrome, Thecoma
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