Acute Inflammation Vascular Changes

Vascular changes in acute inflammation

1.    Vasodilation

2.    Increased blood flow

3.    Increased microvascular permeability with exudation into extravascular tissues

-    Immediate transient response with formation of endothelial gaps in venules

-    Direct endothelial cell injury with necrosis and detachment

-    Leukocyte-mediated cell injury

4.    Increased transcytosis, diapedesis

5.    Leakage from new vessels

-    Stasis, with leukocyte adhesion to endothelium and transmigration into extravascular tissues