Category Archives: Infections

Infectious Diseases

Infectious Diseases

World’s Deadliest Infectious Diseases (WHO, 1997)

Acute respiratory infections, pneumonia

Caused by bacteria and viruses. Around 4-5 million deaths a year.

Diarrhea

Patient usually die from fluid loss and dehydration. Caused by bacteria and viruses. Around 3 million deaths per year.

Tuberculosis

Caused by an indolent and slow growing bacterium. Causes around 3 million deaths per year. Tuberculosis can infect almost any organ in the human body and is very difficult to diagnose and pick up.

Malaria

Caused by a parasitic protozoa. Around 1-2 million deaths per year.

Hepatitis B

Caused by a virus. Around 1 million deaths a year.

Measles

Caused by a virus. Around 1 million deaths a year.

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Infection

Human Infections

Organisms that cause Human Infections and Diseases

Bacteria (by far the greatest cause along with viruses)

Viruses

Fungi

Protozoa (single celled parasite)

Helminths (worms)

Prions (infectious proteins with no nucleic acids; very difficult to degrade and denature)

Characteristics of Infectious Agents and Infectious Organisms.

Bacteria Virus Fungi Protozoa
Size (nm) (approximately) 1,000 200 20,000 20,000
Nucleic acids DNA and RNA DNA or RNA DNA and RNA DNA and RNA
Cell type Prokaryote N/A Eukaryote Eukaryote
Intracellular obligate No but often yes Yes No No
Can culture on artificial media? Yes No Yes Yes

Eukaryotes have a nuclear membrane.

Helminths are complete organisms and are multicellular.

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Gastrointestinal Diseases in HIV

Gastrointestinal Diseases in HIV

Infections

-adenovirus
-CMV
-coccidiosis
-cryptosporidiosis
-intestinal spirochetosis
-anorectal syphilis

Cancer: Dysplasia and Malignancy

-anal condylomata
-anal intraepithelial neoplasia
-squamous cell carcinoma of the anus
-lymphoid neoplasms
-Kaposi s sarcoma

AIDS Enterocolopathy

- consists of Graft versus Host like changes associated with chronic diarrhea in AIDS patients,  in the absence of demonstrable infections
-increased apoptotic enterocytes and decreased number of mitotic figures that would be appropriate for the extent of mucosal injury seen

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