Biology Disease
Drugs and Medicines

Drug Name Mesoridazine besylate oral

Mesoridazine besylate oral Drug Category MESORIDAZINE CONCENTRATE - ORAL

Mesoridazine besylate oral Drug Information

IMPORTANT NOTE: The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your healthcare professional before using this drug. MESORIDAZINE CONCENTRATE - ORAL (mezz-oh-RID-uh-zeen) COMMON BRAND NAME(S): Serentil WARNING: Serious heart problems (QTc interval prolongation) have occurred in patients taking mesoridazine. QTc prolongation can infrequently result in serious, rarely fatal, irregular heartbeats. Consult your doctor or pharmacist for details. Ask for instructions about whether you need to stop any other QTc-prolonging drugs you may be using in order to minimize the risk of this effect. Mesoridazine should be used only when treatment with other drugs have failed. USES: Mesoridazine is used to treat a mental/emotional condition (schizophrenia) that is untreatable with other drugs. It may be used for other conditions as determined by your doctor. HOW TO USE: Take with food or milk if stomach upset occurs unless directed otherwise by your doctor. Your dosage is based on your condition and response to the medication. Take this medication exactly as prescribed. Do not increase your dose or stop taking this drug without first consulting your doctor. Measure carefully and dilute with 4 ounces or more of water, milk, juice or carbonated beverage. It can be mixed into applesauce or pudding. Do not dilute with coffee, tea, colas or apple juice because the medication may lose effectiveness. Take immediately after diluting. Do not dilute the drug and save for later use. It must be diluted before each dose. In the treatment of mental or emotional conditions, it may take up to two weeks for full benefit to be noticed. SIDE EFFECTS: Constipation, drowsiness, vision changes, or dry mouth may occur. If any of these effects persist or worsen, notify your doctor. Tell your doctor immediately if any of these unlikely but serious side effects occur: dizziness, difficulty speaking, loss of balance, mask-like facial expression, trembling or shaking, lip smacking or other uncontrollable movements, difficulty urinating, skin rash/discoloration, muscle stiffness. Tell your doctor immediately if any of these highly unlikely but serious side effects occur: yellowing eyes or skin, vomiting, dark urine, hot dry skin, sore throat, stomach pain, unusual bleeding or bruising. Though highly unlikely to occur, notify your doctor immediately if you experience any of the following very serious side effects: fainting, irregular heartbeat, confusion, fever, seizures, severe muscle stiffness, increased sweating, prolonged/painful erection. In the unlikely event you have an allergic reaction to this drug, seek immediate medical attention. Symptoms of an allergic reaction include: rash, itching, swelling, dizziness, trouble breathing. If you notice other effects not listed above, contact your doctor or pharmacist. PRECAUTIONS: Tell your doctor your medical history, especially: very high or very low blood pressure, liver disease, heart disease, irregular heartbeat, Reye's syndrome, alcohol or drug dependencies, nervous system problems, blood disorders, any allergies (especially any drug allergies). Use caution performing tasks that require alertness such as driving or operating machinery. Use of alcohol can cause extreme drowsiness. Avoid alcohol use. This medication may increase sensitivity to sunlight. Avoid prolonged sun exposure and wear a sunscreen and protective clothing when you are exposed to the sun. This medication can reduce sweating making you more susceptible to heat stroke. Avoid strenuous work or exercise in hot weather. Elderly patients are more sensitive to the effects of this drug. Use cautiously. Children should be monitored closely while using this drug. This drug should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor. It is unknown if this medication passes into breast milk. Certain medications closely related to mesoridazine pass into breast milk and may have undesirable effects on a nursing infant. Consult your doctor before breast-feeding. DRUG INTERACTIONS: Inform your doctor about all the medications you may use (both prescription and nonprescription), especially: anti-depressant/anti-anxiety drugs, guanethidine, guanadrel, metrizamide, cabergoline, lithium, narcotic pain medication (e.g., codeine), drugs that help you sleep, muscle relaxants, drowsiness-causing antihistamines (e.g., diphenhydramine), other drugs that can make you drowsy. Report other drugs which affect the heart rhythm (QTc prolongation), such as: quinidine, sotalol, sparfloxacin, pimozide, procainamide, amiodarone, "water pills" (diuretics such as furosemide or hydrochlorothiazide). Ask your doctor or pharmacist for more details. Many cough-and-cold products contain ingredients that may add a drowsiness effect. Before using cough-and-cold medications, ask your doctor or pharmacist about the safe use of those products. Do not start or stop any medicine without doctor or pharmacist approval. OVERDOSE: If overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms of overdose may include, restlessness, confusion, excitement, weakness, fatigue, fainting, dizziness, rapid or irregular heartbeat, small pupil size, tremors, difficulty in swallowing or breathing, excessive drowsiness, very low body temperature, or seizures. NOTES: Do not share this medication with others. MISSED DOSE: If you miss a dose and take 1 dose daily, take it as soon as remembered unless it is almost time for the next dose. In that case, skip the missed dose and resume your usual schedule. If you take more than 1 dose daily, take it as soon as possible if it is within an hour or so of the missed dose. If not remembered within an hour, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up. STORAGE: Store in original container at a room temperature not higher than 77 degrees F (25 degrees C). Keep away from sunlight and moisture. Do not store in the bathroom. Keep out of reach of children. MEDICAL ALERT: Your condition can cause complications in a medical emergency. For enrollment information call MedicAlert at 1-800-854-1166 (USA), or 1-800-668-1507 (Canada).